Our country builds up little large-scale mouse's genetic mutant storehouse

Our country builds up little large-scale mouse's genetic mutant storehouse
Our country builds up little large-scale mouse's genetic mutant storehouse
The reporter Wang Dan is from holding in Fudan University a few days ago " The study and application of little mouse genetic mutant and disease model " Strategy learns, in " eleven five " at seminar During this time, the biological research institute of the development of Fudan University has already built up little largest mouse's genetic mutant storehouse in the world. It is introduced, storehouse of this mutant includes the strains of mutation of little mouse of over 5000 genes, having covered nearly 20% of the genome of little mouse, its scale is equivalent to total of the global biological relevant strain of medical circle over the last 20 years. The intersection of mutant and storehouse this including 280 know the intersection of people and the intersection of disease and the intersection of gene and corresponding mutant already at present, 447 kinds of candidate disease and genetic mutant, 10 pieces of target genetic mutant of medicine already proved conclusively, 24 are grinding medicine target genetic mutant and a large number of candidate medicine target genetic mutant, 378 kinds of important signals and transferring to and leading the relevant gene of route, and a large number of unknown function genes. The setting-up of this database will be in order to look for, prove disease and important physiological function gene, study the activity mechanism of the relevant life, set up disease animal's model, screens biological mark and medicine target, development innovates preventing from, diagnosis and therapeutic method and offers enormous help. The expert participating in the conference is right " Twelve five " How to further advance little mouse's storehouse construction of genetic mutant and application of correlation technique to discuss during this time. It is reported, at present, all mutant has already passed the little mouse information database (PBmice) Release online, and provide for domestic and foreign researcher.


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