Our country succeed in clone humans family outbreak the intersection of movement and the intersection of movement and the intersection of obstacle and pathogenic gene of bringing out etc.

Our country succeed in, clone humans family outbreak the intersection of movement and the intersection of movement and the intersection of obstacle and pathogenic gene of bringing out etc.
Our country succeed in, clone humans family outbreak the intersection of movement and the intersection of movement and the intersection of obstacle and pathogenic gene of bringing out etc.
Shanghai, December 2 (Xinhuanet) (Qiu Yi, Dai RunMing) From Fudan University, Fujian medical university and scientific research institute of nerve of Chinese Academy of Sciences Shanghai researcher employ showing sonning, checking order technology outside while being the whole advanced, the obstacle (abbreviate as P K D) of moving of bringing out that outbreak moves in 8 families Find in house department that there are 3 kinds that cut short mutation on P R R T 2 genes, and succeeded in cloning the first pathogenic genetic P R R T 2 of family P K D, this pair announce disease member have illness coming on mechanism and raise, treat competence to be significant while being clinical. The result of study is published in U.S.A. " natural science of heredity " online on November 20. Study, attach to first hospital the intersection of lemon and Professor Wang, head the list of signers by the intersection of Fudan University and subsidiary Wu ZhiYing Professor and the intersection of Fujian and medical university, hospital of Huashan, have received the subsidy of national natural science funds and projects of plan of science and technology of Fujian Province. P K D call person who break out, take exercises the intersection of dance and athetosis of bringing out etc. too, one break out repeatedly, the intersection of sport and bring out, the intersection of duration and brief sport obstacle, it is easy to be misdiagnosed as the epilepsy on clinic. Since 1967 after the first report, there are reports about distributing nature and family's venereal disease example successively, family's venereal disease example mostly present dominant heredity of autosome. As far back as the end of 2005, Wu ZhiYing Professor and the intersection of lemon and group that Professor led Wang find a special house department in Fujian, have 16 people who have illness coming on in altogether 78 members of 4 generations, and every generation have patient appear, show as, rise to our feet or start walk or run, appearing pairs of the intersection of upper limbs and the intersection of dance and kinds of movement suddenly from seat mainly, shank and truck are turned back to one side, fall down unstable while standingly when being serious, lasting stops from several seconds to several dozen seconds, break out repeatedly, can break out several dozen times every day, consciousness knows while breaking out. Is consulted the literature and discusses, consider this is a kind of family P K D repeatedly. Collected 7 house departments similar to the symptom successively also later. 2010, study group, show son check order technology apply the intersection of P K D and the intersection of house and gene of department to, clone and have outside while being the whole, materials checking again 8 pieces of home are, in most large the intersection of house and department, choose two representative patient and 2 the intersection of house and the intersection of department and member to have symptom analyze in the the intersection of house and department that Fujian find promptly, have obtained more than 100 hundred million nucleotide array data together, combine the result of study of genetic localization and domestic and foreign literature in earlier stage, lock the goal P R R T 2 genes of the chromosome on the 16th rapidly, further check order to prove directly that finding P R R T 2 genes cuts short mutation, this result has been verified in other 7 departments of the intersection of P K D and house, have found 3 kinds and cut short sudden change together, and prove in 1000 health contrast person, have got rid of the possibility that three kinds of above-mentioned mutation are many attitudes of gene. For the relation while canvassing the albumen function of P R R T 2 and having illness coming on with P K D, researcher and the intersection of Chinese Academy of Sciences and the intersection of Shanghai and nerve scientific Xiong Zhi strange researcher's team unity of research institute again, set up a high-efficient team, finished P R R T 2 gene expression and albumen to make a reservation to study within short time, it is the pathogenic gene of P K D that the result is further briefed on P R R T 2. This job was totally finished at home independently, adopted the most advanced molecular biology technology, have solved the difficult problem that has perplexed the domestic and foreign scholar over the past 20 years ingeniously. The cloning of P K D gene has important reference function to the outbreak diseases of other types too.


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