The scholar of our country develops the unique fluorogenic probe Realize to coenzyme of cellular metabolism that strikes recording in real time

The scholar of our country develops the unique fluorogenic probe Realize to coenzyme of cellular metabolism that strikes recording in real time
The scholar of our country develops the unique fluorogenic probe Realize to coenzyme of cellular metabolism that strikes recording in real time
It is reported ' The reporter reporter Yao YanYan and Hu DeRong) Shanghai East China University of Science and Technology Professor Yang Yi seminar develops the fluorogenic probe of the uniqueness recently, realize it to living in cells and various inferior cell structure for the first time in the world " Reducing two nucleotide of niacinamide adenine (NADH) " Real-time trends, specific detection and formation of image of the molecule, their theses were published on the latest internationally famous academic publication " cell - supersession " magazine a few days ago. NADH is the most important coenzyme in the organism, participate in the material, energy supersession, signal of cells to transfer to and lead adjusting and controlling with the gene extensively, in close relations with a lot of diseases such as cancer, cardiovascular vessel disease, diabetes, neural regression disease. Yang Yi seminar utilizes formating the biological method, has developed a series of fluorogenic probe of hereditary code to measure NADH, determine the distribution level of free NADH in different inferior cell structure of human cell accurately for the first time, " whether like film can see mankind and glucose metabolism, mitochondria breathe the chain function, oxidize and reduce and adjust and control NADH supersession situation under terms in the mammalian cell " ,And find NADH can be entered and adjusted and controlled many kinds of life activities in cells freely across the membrane. Yang Yi thinks, this result of study will be offered for further studying and observed and organized with the distribution of NADH in cells with the technology of the formation of image of living beings, running situation, supersession situation tool and means of cells of cells, can carry on the survey, video of the space-time resolution ratio high and take a picture to the supersession situation of cells at the same time, all right localization or orientation any place and position are measured, contribute to understanding cell inner material and regulation mechanism of the energy supersession better.


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