The scholar of our country found and formed the new target of rectal cancer

The scholar of our country found and formed the new target of rectal cancer
The scholar of our country found and formed the new target of rectal cancer
It is reported ' Reporter Li TianShu) A few days ago, the nutrition of research institute of Shanghai life of Chinese Academy of Sciences was square to pacify one that the seminar finished to discover, hydroxyl enzyme 3( PHD3) proline Play an important role in forming rectal cancer, closely related to malignant intensity of tumour. This research results are published in " the intestines and stomach disease is studied " the magazine. It is mankind's common digestive tract tumour to form rectal cancer, it is closely related with that onset and change and meal structure of the life style are unreasonable. At present, the whole world increases the case newly and counts Damien 940,000 every year, nearly 500,000 people die of and form rectal cancer every year, occupy the third of cause of the death of cancer. In our country, forming rectal cancer occupies the 4th of morbidity of malignant tumour, and show a tendency to obviously rise. The proline hydroxyl enzyme family includes PHD1, PHD2 and PHD3. And then pacify the seminar and form the clinical sample of rectal cancer through analyzing, find the expression level of PHD3 is obviously lower than forming the rectum PHD3 while organizing normally in tumour, and the expression level of PHD3 is presented and obviously defeated by with grading and transformation of tumour relevantly. Animal's experiment reveals, inhibits PHD3 from expressing, can be in order to accelerate the growth of tumour cells and production of tumour notably. The expert points out, this result of study announces the new function of PHD3, contribute to knowing the growth mechanism of forming rectal cancer.


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