A disease of brothers deactivates vaccine and enters clinical research stage

A disease of brothers deactivates vaccine and enters clinical research stage
A disease of brothers deactivates vaccine and enters clinical research stage
The reporter learnt from the traditional Chinese medicines group a few days ago, the EV71 type researched and developed from the national project centre of new vaccine of the group company of Chinese biotechnology under this group deactivates vaccine (71 type brothers' port disease and intestines virus) Have deactivated vaccine and already obtained the official written reply of clinical research of national Bureau of Drugs Supervision formally, will enter clinical observation stage soon. According to the secretary of board of directors of traditional Chinese medicines group, Sheng's happy introduction of press spokesman stone, the reseach of this vaccine lasts two and a half years, it is a great breakthrough of the research field of vaccine of our country, also the first clinical official written reply of a kind of new medicine with independent intellectual property right which the new traditional Chinese medicines group gets after recombinating. Have not seen the formal report sanctioned in the global range clinically about this kind of vaccine yet at present. The virus infective disease not paid attention to of each, after listing in legal infectious disease for two years, namely have illness coming on and count the first as class-C infectious disease rapidly - -Brothers' mouth disease, this kind occurs frequently to break out and cause the death case and cause the extensive concern in all parts constantly in the cause of disease of infection of the infant and pre-school children under the age of 5 in recent years. In March of 2008, take place and break out to lead to the fact at least on mouths of brothers of Fuyang of Anhui 23 children die, thus cause the general attention of government and drugmaker. In May of the same year, Ministry of Public Health listed it in infectious disease and prevented and cured the class-C infectious disease that France stipulated and paid and managed. According to the introduction of expert, peak period when brothers' mouth disease has illness coming on is generally in May - July. Can be seen to prevent and cotrol the data that the office announces from disease of Ministry of Public Health: By May 4, 2010, our country has already reported to 427278 ill cases of mouths of brothers totally, has increased by 41.51% compared with the same period of 2009, 5454 serious diseases among them, 260 cases of death. By July 22, 2010, report brothers' mouth disease case 1280981 to totally in the whole country, the serious disease case 20437 among them, 692 people die. Morbidity case and serious disease case of increasing so rapidly, making the mouths of brothers ill becomes the focus that government and the public pay close attention to. Epidemiology chief scientist Zeng Guang of Center for Disease Prevention and Control of China says, in cases lacks valid treatment means and vaccine and has not succeeded in developing yet, in the will it be some time future, brothers the intersection of mouth and disease in high to take place the situation also. The soaring that is counted with the serious disease case, some district health bureau unites Municipal Education Commission and sends out the notice of suspending classes. In 1957, the first brothers' mouth disease case was found in Canada; In the seventies of the 20th century, EV71 virus was first affirmation in U.S.A.. Near and from 10 to 20, brothers the intersection of mouth and disease all district had to break out different scale in world, include successively prevailing in Chinese Taiwan, Hong Kong area and Malaysia. Before breaking out popularly, lack the research of the rival foot port in China, rarely seen and relevant scientific findings. The expert thinks, the reason why brothers' disease fond of salty food, death case increase, is lacking the effective antiviral medicine. At the clinic, course of disease change fast and recessive symptom to cause main causes of death. " It is introduced, the course of disease of the intersection of brothers and the intersection of mouth and disease is changed perhaps very fast, EV71 serious disease infects and presents nervous system symptom within 10 hours, have increased the difficulty treated and cured. In addition some case might not have typical sign in initial stage, for example die in the case in 19 that Guangxi take place will it be April this year, have not mostly presented rash. Vaccine enter clinical research as far as reporter know, brothers 2 to 7 days in incubation period in disease in mouth, infect source, include patient and recessive the infeted, travel through digestive tract, respiratory tract, the intersection of person who keep in close touch and route mainly. The expert thinks, in a situation that diagnosis, therapeutic method are limited at present, prevent the links which become key. Mainly carry on disease control, such as sanitation and hygiene, isolating, reducing to keep in touch, propagating and educating, going to a doctor etc. in time through the means of the general behavior at present, the most ideal measure is to control the prevalence of disease through vaccine. In May of 2008, in the critical moment of this epidemic situation, the State Ministry of Science and Technology sets up promptly, starts " eleven five " Science and technology support plans the emergency item " The mouths of brothers are ill (EV71 type) The reseach of vaccine " . This project regards national project centre of new vaccine of group affiliated China biotechnology group company of traditional Chinese medicines as and takes the lead in the unit, assay the research institute with the Chinese medicines biologicals, the unit that CDC virus waits for makes up the seminar, it is ill to launch the mouths of brothers (EV71 type) Reseach of vaccine. Under the energetical support of centre of development of Ministry of Science and Technology and China biotechnology, the seminar goes through two and a half years to tackle key problems, finished the research work before the EV71 type deactivates all such as the design, pilot scale, validity test, security appraisal, quality control of vaccine clinically two years ahead of time. The result of study verifies tentatively, the standard advanced person of this vaccine, quality are controllable before clinic; The existing animal experimental result shows, this vaccine can carry on clinical research. EV71 type will deactivate vaccine to examine and comment the expert that the centre organizes and examine and comment through SFDA medicines in June of 2010. On December 24, every examination and approval procedures have already been finished, EV71 that the traditional Chinese medicines group has been signed and issued by SFDA deactivates the vaccine clinical research official written reply. Carrying on the clinical preparation at present, will enter clinical research. This it is country that continue high effective act that take place in conformity with the intersection of rival and the intersection of foot and the intersection of port and. Get off so, it will be expected to take the lead in being listed China that first brothers' mouth disease global deactivates vaccine.


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