My scientist finds two pieces of cancer of the esophagus and exchanges the sense gene

My scientist finds two pieces of cancer of the esophagus and exchanges the sense gene
My scientist finds two pieces of cancer of the esophagus and exchanges the sense gene
It is reported ' Reporter Li TianShu) August 22, the internationally famous academic periodical " natural science of heredity " (NatureGenetics) Have issued a result of study headed the list of signers by cancer Professor Wang LiDong, director of research center of medical college in Xinxiang online: Find two pieces of cancer of the esophagus and exchange the sense gene (PLCE1 and C20orf54) on mankind's chromosome No. 10 and No. 20 for the first time . The research is that it is analysed and researched that the largest the whole genome of cancer of the esophagus is related in the world so far. It is introduced, the research group that Wang LiDong headed utilizes related analysis (GWAS) of the whole genome Technology, through comparing and analysing over 25,000 the Han nationality, Kazak and Uygurs of China,etc. different nationalities and patient and health control group of regional cancer of the esophaguses, find different nationality and the intersection of cancer of the esophagus and patient of area these, closely related with with PLCE1 and C20orf54. In other words, many attitudes of these two genes can indicate the risk which suffer from cancer of the esophagus. This research results not merely help the scientist to analyze the morbidity mechanism of cancer of the esophagus thoroughly, and prevented and treated for prewarning of high-risk group of cancer of the esophagus, early diagnosis, individual and the screening of the new high-efficient medicine is offered theoretical foundation and molecule target. In addition, the research in the high taking place area of cancer of the esophagus of Henan Province of scientist of older generation of our country has already been verified, one of the important dangerous factors that cancer of the esophagus happens that the riboflavin lacks. But the obvious individual difference exists in the intervention result caused to supplement the riboflavin of meal. The intersection of research and riboflavin that group find this transship genetic C20orf54, change, might announce such individual member foundation of difference to a certain extent. In our country, have the same prevailing region characteristics to cardia cancer and cancer of the esophagus of esophagus and the intersection of stomach and juncture department, the area of namely cancer of the esophagus with high morbidity, the morbidity of cardia cancer is very high, pointing out the two may have similar dangerous factor of morbidity. While this research is finding cancer of the esophagus and exchanging the sense gene, also verify these exchange sense gene and cardia cancer but closely related with, have announced from the molecule level cancer of the esophagus and cardia cancer may have similar morbidity mechanisms. It is introduced, this research is cooperated with Anhui medical university by Xinxiang medical college, utilize the intersection of Anhui and the whole genome that medical university set up related to analyse and research platform and the intersection of China and the Hans, contrast the whole genome and concerned with the analysis database normally, unite 17 provinces ' Market) 50 tumour scientific research institutions sum scientific research institution finish together.


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