The scientific research personnel of our country find tumour cells adjust and control key factor and new mechanism

The scientific research personnel of our country find tumour cells adjust and control key factor and new mechanism
The scientific research personnel of our country find tumour cells adjust and control key factor and new mechanism
The intersection of www.chinanews.com and the intersection of Beijing and July 27 cable (base Shen, army of will, Wu fly to) Recently, military academy of medical sciences spread the news that it is good again, this institute national biomedical piece, director of analysis center, study quick the intersection of scientific research and group, grow and adjust and control in the research making the important break-through in tumour, find the intersection of tumour and the intersection of cell and key factor and new mechanism that cycle adjust and control, for the intersection of tumour and to treat, study, offer new the intersection of target and member target. This research work has been already the internationally famous academic periodical " natural cell biology " (NatureCellBiology, influence the factor 19.5) The magazine accepts formally and issues online. The research is finished under subsidy of project such as national natural science fund and national 973 programme. As everyone knows, cancer was developed by the normal cells in the human body as a kind of malignant tumour. The cancer cell is like a runaway wild horse, after breaking away from the normal constraint of the human body and adjusting and controlling, know the hyperplasia of ground with no limits. If does not treat in time, will transfer to every place of whole body to grow and breed, lead to the fact rapidly finally the human internal organs function is severed, until dying. Current society, one may well say everybody strikes torror at the topic of cancer. It is reported, U.S.A.'s cancer patient's quantity proportion has risen to 1/20 sharply in recent years. In 2007, about 11,700,000 Americans suffer from cancer. The newest official statistical data revealed, the death toll of China's cancer accounts for 1/4 in the world in 2011, and the morbidity presents the younger trend year by year. Cancer grows in intensity, endanger greater and greater, but today highly developed in science and technology, global scientist has not taken out basic method which deals with cancer, how to control and treat cancer and already become world difficult problems effectively. So, tumour treats the research of the field and concerns human health, make any important break-through, meanings are all very great. In a large number of experiments and clinical research, the scientist finds cell cycle adjusts and controls one of the characteristics that the disorder is tumour, and the emergence that briefs on tumour may be that cycle adjust and control the unusual result. It is under the accurate adjustment of the relevant gene that cell cycle adjusts and controls the mechanism, run according to certain rule and rhythm, and determine the growth, division of cells and die. At present, direct the intersection of cell and antineoplastic of cycle against, such as the intersection of colchicum and plain and the intersection of Japanese yew and alcohol,etc., lack the specificity to tumour cells, there are malicious side effects to produce and able to bear shortcomings such as medicines,etc. greatly and easily, have brought the great difficulty to clinical treatment. So, find it is a new route to develop specific antineoplastic of new generation that the peculiar cell cycle of tumour cell adjusts and controls the factor, for the intersection of tumour and the intersection of molecule and to treat, offer the new medicine target target. Seminars such as researcher Zhang XueMin,etc. pass to analyze to immune group of a large number of clinical tumour samples, find CUEDC2 expresses high in many kinds of tumours are organized, and can cause the not production of chromosome of whole time of body of cell, cause the unstability of the genome finally. This research comes from a very accidental discovery, the strip of protein which CUEDC2 protein existing in the form of two strips moves in having silks to split one and appear completely, it proves, CUEDC2 protein is having silking that is splitting the phosphorylation that CDK1 kinase happens and catalyze in one to further study, and then promote closing the effective activation of E3 enzyme in time and suffused with usually melting with APC/C of body check point of the spindle, start silk to split and enter later stage. The research has also announced thoroughly CUEDC2 protein passes and promotes the dissociation of protein complex Mad2 and APC/C complex of check point of body of spindle, it is active to release enzyme of APC/C, has expounded the brand-new mechanism closed in right time of check point of the body of spindle. In addition, the question that especially merits attention is, unusually high CUEDC2 protein that expressed in a large number of different tumours, cause spindle body check point close while being premature and APC/C activate ahead of time, thus lead to the fact polyploid wait for the intersection of genome and unstability take place with tumour taking shape. Such biological function of CUEDC2 protein makes it become new target of an ideal to the treatment of molecule target of tumour, and probably further develop into high-efficient, peculiar and low-toxicity antineoplastic on this basis. (End)


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