The scientist of our country announces insulin is resisted the new mechanism to happened

The scientist of our country announces insulin is resisted the new mechanism to happened
The scientist of our country announces insulin is resisted the new mechanism to happened
It is reported ' Reporter Li TianShu) On January 5, issued the latest research results of the research institute of Shanghai life of the Chinese Academy of Sciences online for Nature. This achievement has announced insulin resists the new mechanism that takes place, has offered the new thinking for therapeutic method of 2 type diabetic medicine. In normal cases, insulin can activate the insulinogenic signal thorough fare in the muscle, liver, adipose tissue, thus reach the function of lowering blood glucose. But in the 2 type diabetic patient, this important function of insulin is damaged, the periphery is organized ' For instance muscle, liver, adipose tissue,etc.) To the insulinogenic sensitiveness decline, thus cause the emergence of the 2 type diabetes directly. Insulin resists and 2 type the morbidity of diabetes and correlates with factors such as heredity, fat and bad life style,etc., but its molecular mechanism is not so obvious so far. By discover for a long time seminar that Gang Pei lead, academician of Chinese Academy of Sciences, a kind of signal albumen �� - arrestin2 with multiple function can form signals and transfer with the insulinogenic receptor to and lead and compound the body, �� - arrestin2 is that this signal compounds the structure core of the body, it unites insulinogenic receptor and kinase signal molecule of the low reaches of the upper reaches occasionally, thus has promoted sensitiveness to insulin of the organism. The reducing or function of �� - arrestin2 level is lacked, so this signal can't take shape to compound the body normally, have caused insulin resisting and emergence of the 2 type diabetes directly. Researchers find, 2 type diabetics and little mice �� - arrestin2 of model express and reduce notably, and supplement �� - arrestin2 and relieve insulin resisting and symptom of the 2 type diabetes effectively. Relevant experts think, the research has not merely announced insulin resists the new mechanism that happens with 2 type diabetes, and offered the new tactics that can be drawn lessons from for insulin is resisted and treatment of the 2 type diabetes, brief �� - the intersection of arrestin2 and albumen and �� - the intersection of arrestin2 and albumen on / insulinogenic receptor compound body to be expected to become, research and develop insulin resist relevant supersession the intersection of disease treatment and medicine The new target is clicked.


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