The scientist of our country clones the little mouse of living subject out with iPS cells for the first time

The scientist of our country clones the little mouse of living subject out with iPS cells for the first time
The scientist of our country clones the little mouse of living subject out with iPS cells for the first time
This newspaper the intersection of round-up news and Qi Zhou, scientist of Chinese, and high to continue honour,et al., utilize iPS cells for the first time ' Induce the multi-functional stem cell) Clone the mouse of experiment made on the living out, thus verify iPS cells are as all-round like embryo's stem cell. First iPS cells clone mice and is named as " It is small " ,Its photo has boarded the front page of the numerous media's websites of America and Europe. It is " small " Founder one of, introduce at Chinese Academy of Sciences animal research institute researcher Zhou Qi, it is " small " If you can't get along with, lie in not using by iPS cell. The stem cell is the people and the animal can be turned into various cells of organs and tissues in the body, this characteristic of it is known as all-roundly. Can only get the stem cell from the embryo all the time in the pasting, ethics is being disputed and got up therefrom. In 2007, American and Japanese scientist claim respectively to find that " models " ordinary cells such as skin cells,etc. Stem cell method, the stem cell that gets like this is called inducing the multi-functional stem cell, have another name called iPS cells, thus has prevented ethics from disputing. This discovery is chosen as the global great science progress that year respectively by " Nature " and Science. Though iPS cells have broad application prospect in the biological and medical field, it really has embryo's so all-round stem cells, thus is really a match for embryo's stem cell in medical treatment is employed? Research group members, the researcher of Shanghai Communications University, once all a pair of reporters, say, cells prove whether it has an all-round one to could cultivate the little mouse with iPS " The gold standard " . The research in the world fails all the time before, the little mouse foetus that fosters with iPS cells fails before being carrying out. According to July 23 report of British Nature website, Qi and Beijing Zhou life sciences research institute high to continue research group that honour lead, utilize same genetic technology cultivate the mouse of experiment made on the living basically respectively a few days ago. Among them, Zhou Qi's research group has succeeded in fostering 27 and testing mice, and clone first iPS cells the mouse names as " smallly " . "It is the grandfather that it is ' small ' people has cloned mice. " Once all said, the research group cultivated and cloned the little mouse last October. Succeeded in fostering 27 and testing mice together at that time, though died after some of them were born for two days, some has unusual bodies, but all 12 that are used for mating test mice and succeed in producing the offspring, and the second generation of these do not have abnormal phenomenon. They have born several hundred the second generation of experiment mice, and already had over 100 the third generation of experiment mice. It is reported, the high research group which continues the honour succeeds in cultivating two and testing mice too with basically the same technology, but one of these dies. At present, this group is trying to test mice and mate to another one, in order to foster the little the second generation of mouse. The relevant thesis will be published on the magazine of U.S.A. " cell stem cell ". In Pittsburgh of U.S.A. what is visiting is continuing the honour to introduce to the reporter of Xinhua News Agency through the E-mail high, experiment methods that the fine jade seminar adopts of his seminar and week are different, what the fine jade seminar used while fostering iPS cells is to go against to duplicate the virus in week, and what he used is slow virus. In addition high to continue the intersection of honour and little the intersection of mouse and the intersection of body and cell that seminar cultivate without accede to the transcription factor, can continue and use, because 4 kinds of transcription factors used have already been combined in little mouse's genome while fostering iPS cells, can be according to the recombination efficiency of different iPS cells of this research, thus confirm which type of body cell is suitable for fostering iPS cells. The report of British Nature website praises a Chinese scientist " Have opened up a brand-new road in order to clone the adult mammal " ,Point out method this clone method to be more high-efficient, safer than tradition. The report still quotes the words of Chinese scientific research personnel, they do not plan to develop technology of human cloning on this basis. Gao ShaoRong says, this research results are to march toward a great step in the real medical course from stem-cell research, have important value to stem cell's all-round mechanism research and organ transplant, medicine screening, gene therapy,etc. clinical application study,etc..


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