The scientist of our country deciphers and gives a birth to start the route

The scientist of our country deciphers and gives a birth to start the route
The scientist of our country deciphers and gives a birth to start the route
It is reported ' Reporter Wang Dan) Premature delivery not only encloses the neonatal main causes of death in childbirth period, and influence the early newborn baby's health after growing up directly. However, because the mankind starts the mechanism in giving a birth without totally expounding yet, still lack the effective means to prevent and cure premature delivery. In recent years, Fudan University university student order that professor head seminar, Sun Gang of academy of sciences, launch, study while being a series of to above-mentioned problem, find the formation that glucocorticoid existing in fetal membrane can promote prostaglandin in later period of human gestation, meanwhile, glucocorticoid can be produced oneself constantly, thus promote the above-mentioned step to implement. This research results, in order to expound the mankind gave a birth to start the mechanism to offer the new break-through point. Relevant serial articles will already be published on magazines such as " clinical endocrine and supersession " and " member's endocrinology ",etc. in the near future, and is recommended in order to transform the medical light spot by " member's endocrinology ". It is introduced, the incidence of global premature delivery accounts for the pregnant 7%~15% of mankind, and is on the rise. Though the mechanism of starting is comparatively complicated that the mankind has given a birth, prostaglandin has started the final common path of giving a birth and already reached common understanding in the academia. Discover, glucocorticoid not merely can promote the maturity of foetus' organ in later period for gestation, the ones that can also promote the fetal membrane to organize prostaglandin are synthetic, the latter is considered to give birth to one of the important factors of starting. So, verify glucocorticoid and promote the synthetic mechanism of prostaglandin of fetal membrane, offer the effective means, one of the hot problems already paid close attention to as the domain of international healthy reproduction for preventing and curing premature delivery. Technology that the seminar that Sun Gang headed adopts the real-time quantitative polymerase chain reacting, albumen blot hybridizing, chromatin immunity to precipitate,etc., formate the main cell type of prostaglandin to people's fetal membrane - -The amnion pays discovering as fibrous cells, induction function and phosphorus adenosine of ring caused from this / protein kinase A / ring phosphorus adenosine of glucocorticoid to activation type ��'s inferior base of G albumen react in the tuberculosis albumen thorough fare of the component Activate, it is the key to leading to the fact it promotes people amnion prostaglandin to be synthetic. Meanwhile, glucocorticoid activates enzyme 11�� - hydroxyl steroids and takes off the induction function that the hydrogen enzyme type expresses to it, active glucocorticoid to can produce more one, thus further promote the formation of prostaglandin. Study to find, progestogen and receptor A are inferior type can pass, compete with glucocorticoid the receptor at the same time, and inhibit the glucocorticoid receptor from duplicating the activation and weaken the function of glucocorticoid in giving a birth and starting. The above-mentioned research results are offered the new thinking in order to develop the medicine to prevent and cure premature delivery effectively.


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