The scientist of our country finds and treats systemic lupus erythematosus " The new key "

The scientist of our country finds and treats systemic lupus erythematosus " The new key "
The scientist of our country finds and treats systemic lupus erythematosus " The new key "
Www.xinhuanet.com Shanghai 8 Cable of the 25th of moon (Qiu Yi, Sun GuoGen) Study through 12 years, chief scientist of great project of the national natural science fund, Fudan University immuno-biology research institute and biomedical bear of research institute of Suzhou university think in the seminar which the east professor headed, lead first discoveries such as its student, the main participant of project Dr. Zhang WeiJuan,etc., can there is one kind one kind of albumen P compositions (S A P albumen) of starch of important serum in combination with D N A in human serum normally ,And propose " S A P albumen " for the first time Have new function of treating the systemic lupus erythematosus. Relevant research results issue, learn the proceedings " amynologic magazine " in international the intersection of immunology and authoritative immunity, U.S.A. of magazine, that publish newly in succession already ' <>) With the comprehensive periodical of the internationally famous public science library <

>. After two theses are issued, cause the extensive concern of the domestic and foreign scholar at once, the latest serial magazines of " Nature " <> foreign expert of special publication thinks" this research briefs on " to the important commentary of this achievement: It is a new therapeutic method to supplement S A P albumen for the systemic lupus erythematosus patient, it has opened up the new route in order to treat systemic lupus erythematosus " . Systemic lupus erythematosus influences crowd's most extensive, most serious one's own immunity to be ill, clinical manifestation is damaged for erythema of facial butterfly's shape, generating heat, skin damage, joint swelling and aching, kidney, half the number patient is still shown as lupus pneumonia, psychonosema,etc., many finally because the organ function is depleted to cause the death. The morbidity of systemic lupus erythematosus is soaring in the whole world constantly, the morbidity is 3 5 / 1 0 Wan, and the morbidity of our country is higher, reach 7 5 / 1 0 Ten thousand. Among them, though until treatment means progress, lupus nephritis victim survival rate improve to present 82 from 44 of will it be the fifties the 20th century already 5 year, but its average life span is only 44 years old. Systemic the intersection of lupus erythematosus and clinical manifestation and have illness coming on mechanism to be extremely complicated, still have a lot of unidentifieds, bring the great difficulty for the clinical specific treatment to the cause of disease. So, further study and have illness coming on the mechanism is that immunology and clinical rheumatism in the world learn the key problem that workers pay close attention to with discussing and treating the tactics clinically. Bear think east seminar discover a large number of activate D N A composition release of cells and pile up in serum by oneself for a long time, closely related to emergence, developing of the systemic lupus erythematosus, and remove in the human body D N A that excessive oneself that piles up activates the cell source may be that the specificity prevent and treat the new route of the systemic lupus erythematosus. In go on, find analyze, to a large number of the intersection of lupus and patient and the intersection of lupus and little the intersection of mouse and the intersection of serum and index SiDong Xiong,etc., " S A P albumen " in the lupus patient and body of little mouse of lupus Production getting more insufficient obviously in competence,last S A P albumen one that is in disease in early days can prevent from lupus' lasting lupus the emergences of the nephritis,etc.s effectively, if supplement S A P albumen in the serious one of disease, can obviously reduce the destruction of organization of the little mouse of lupus and lighten nephritis symptom. The proposition for the first time in the world of this achievement supplements S A P albumen to prevent and treat systemic lupus erythematosus for the lupus patient, it may be a specific, effective therapeutic method directed against the cause of disease. Important molecular mechanism that has preventing and therapeutic effect for basic reason and S A P protein that further look for systemic lupus erythematosus to have illness coming on, Xiong SiDong,etc. concentrates the focus on the patient correctly " The lethality " On the greatest lupus nephritis. Found finally, compared with little normal mouse kidney, will present a large number of macrophages in the tissue of nephritis of little mouse of lupus. Macrophages are important in the human body " Sentry " ,Under the normal situation, it engulfs the function which removes internal foreign matter, there is little quantity in renal China. But in case of disease, macrophages may lose the normal protection function to the organism, and turn into pathogenic macrophages. Xiong SiDong,etc. discovers, give to the little mouse supplementary " S A P albumen " in kidneys And then, inferior group of macrophage of such pathogenic function is obviously reduced, the substitute is present a large number of inferior group of macrophage with protective actions. This new discovery has announced " S A P albumen " for the first time Have illness coming on at systemic lupus erythematosus and neutralize the key effect in adjusting and controlling the type of splitting up of macrophage to change. The research results have offered a specific new tactics for preventing, also effective medicine targets for further studying the morbidity mechanism of the systemic lupus erythematosus and looking for some more pointed reliable, effective medicine targets fed. (End)


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