The scientist of our country finishes the key structure of bird flu virus to analyze

The scientist of our country finishes the key structure of bird flu virus to analyze
The scientist of our country finishes the key structure of bird flu virus to analyze
It is reported ' Reporter Li TianShu) A few days ago, scientists of our country obtained breaking through in bird flu virus research importantly: Have revealed the important life machine of the virus - -The working mechanism of ribonucleic acid polymerase PA inferior base, has offered the new target for research and development of the relevant medicine. The researchers of Ins of Biophysics,Academia Sinica, Nankai University and Tsing-Hua University, have analyzed the remaining amino end (PAN) of bird flu virus RNA polymerase PA inferior base High-resolution crystal structure,thus not last polymerase for influenza virus PA structure research works biological of bases inferior. Their result of study has announced PA albumen have cores to cut enzyme function impractically inside. This result has overthrown PB1 inferior base reported in the past and compounded the inference of exercising this function in the body in polymerase. On February 4, issued this research results online in " nature ". The ones that it is introduced, bird flu virus contains 8 RNA genome passagesed were defeated by the chain RNA virus, have already known that be able to encode 11 kinds of virus proteins. Among them, PB1, PB2 and PA, the inferior base of 3 proteins is making up the important life machine of influenza virus - -Influenza virus RNA polymerase. In the duplication at bird flu virus and course of infection, influenza virus polymerase has played an essential role, functions in many aspects that duplication and virus mRNA that it is responsible for exercising the genome RNA of virus are duplicated,etc.. Study the structure of influenza virus polymerase, not merely to announcing the function mechanism of influenza virus polymerase is significant, can also offer the molecule model for research and development against virus medicine on clinic. Under the support and subsidizing of the National Natural Science Foundation of China, Ministry of Science and Technology and Chinese Academy of Sciences, basic structure that of RNA polymerase compound the body PA inferior base that researchers have analyzed H5N1 poisonously systematically progressively. Researchers infer through an analysis of this structure this albumen is probably sour sure enzyme inside of a core with new structure. In view of the above, they have launched a series of molecule biological study, have verified the conjecture that makes according to the analysis of structure is correct. It is reported, this conclusion has announced clearly PA participates in an important molecular mechanism that the virus duplicates the function for the first time, prove bird flu virus RNA core not had sour to cut enzyme inside function at the intersection of PA and inferior base in the polymerase also at the same time, but not on PB1 inferior base. This result of study has not only announced the function mechanism of PA, has but also offered the new route for research and development of the relevant medicine.


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