The scientist of our country succeeds in drawing the human liver protein interaction network chain picture

The scientist of our country succeeds in drawing the human liver protein interaction network chain picture
The scientist of our country succeeds in drawing the human liver protein interaction network chain picture
Cable of October 16 of www.chinanews.com Beijing (Zhen Bei) The military academy of medical sciences radiates with the radiation medical research institute, protein group study national key the intersection of laboratory and dawn researcher and Fu He Ming Yang the scientific research group that the academician lead unite Fudan University for the first time, research thesis " Towardanunderstandingoftheproteininteractionnetworkofthehumanliver eininteractionnetworkofthehumanliver nliver " which advantage units such as Hubei university,etc. finish ,Issued in latest " member systematic biology " magazine on October 11, 2011. This thesis has explained the biggest human organ protein interaction network chain picture frame in the world at present, indicate our country enters the advanced international standards in human protein interaction network research field. The life organism is composed of proteins " The molecule society " ,Just like human society, each protein needs protein different from a lot of to interact, form the complicated relation network and coordinate and command almost all the lives activity, so the intersection of protein and the intersection of interaction and chain that interaction obtain atlas to understand the intersection of protein and " the book from heaven " Importance " The key " The first. It is estimated, human protein is probably 130,000 to interaction, all known data only determine at present that is less than 8%. Researcher Yang XiaoMing and He Fu aim at the front, cooperate open in the scientific research group which the academician led for the first time, rely on the protein group and study the national key laboratory, have set up nationwide joint study system and interacted and studied the platform with internationally advanced high flux, automatic protein. Screen 5026 kinds of human liver protein interactions, obtain 3484 kinds of high credibility interaction between 2582 kinds of liver proteins together, among them 92% of the interaction is the human first discovery. This achievement has also announced the peculiar interaction characteristic which expresses protein, supersession enzyme, liver disease and protein and important signal molecule of thorough fare of liver, having offered 63 not protein function clues of explanatory note, 135 signals transfer to and lead the potential handing in uniting the molecule each other among the thorough fares, and predicted 21 liver cell cancer and relevant protein. This research results are adopted " Once the key link is grasped, everything else falls into place " Research tactics last protein interaction network frame, have offered the thinking of research that can be drawn lessons from for studying similarly; Adopt the function of explaining human organ of interaction network of protein to adjust and control the characteristic for the first time in the world; In order to know the emergence molecular mechanism of liver disease and prevent, diagnose the mark thing and treated the discovery that clicked of the target and established the foundation. High flux, of overall importance to study particular all biosystem interaction of protein focus and difficult point that study both at home and abroad in network. European Union, U.S.A., Canada wait, launch, interact large-scale the intersection of research and plan of group to different protein of species successively. This research is that the Chinese scientist takes the lead in putting forward in the world " Human liver protein group's plan " Important for research contents one of,indicate this achievement whether last new progresses important again research in plan. (End)


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