The new technology can urge producing and bone regeneration of blood vessel

The new technology can urge producing and bone regeneration of blood vessel
The new technology can urge producing and bone regeneration of blood vessel
It is reported ' Reporter Li TianShu) A few days ago, a research thesis that the Chinese Technology Association and China science and technology news learnt to be recommended together was pointed out, the scientific research personnel of our country research and develop one kind and promote producing and regenerated new material of bone of blood vessel recently - -One pair of genes expresses and recombinates the relevant virus carriers of gland together. Animal's experiment verifies, this carrier can carry skin growth factor (VEGF) in the blood vessel at the same time And the albumen (BMP) takes place in the bone shape The gene, has offered the experiment foundation for early gene therapy of osteonecrosis. This research is issued on the latest " China's pharmacology journal ". Ischemic necrosis of the head of femur is the disabling rate of domain of dept. of orthopedics. With the development of genetic therapeutics,beyond last gene therapy of characteristic source, it is a new hope brought in treatment which is short of blood necrosis of head of femur. In order to well combine purpose gene and target cell, the research group that the modest professor led of dawn of second affiliated hospital and a subject party of bone of medical college of Xi'an Communications University, using has the virus carriers without characteristic such as being original and with wide host range - -Recombinate the relevant virus of gland. It is introduced such small carrier can promote the blood vessel turn into and the regenerated gene of bone is transported to the night chief cell, the gene is being duplicated in the constellation chief cell constantly, and there are steady long-term expressions. It is introduced, VEGF and BMP considered to be the thing that repairs the key material with extremely important function to bone regeneration. VEGF is that the main blood vessel produces the factors, BMP known at present and only has malposition to become the cell factor of bone ability. Result of study in recent years brief on, VEGF and BMP might act on different stage that bone form and have cooperative effect. So, researchers think out a kind of novel method, through " loading " VEGF gene and BMP gene together In recombinating the relevant virus carriers of gland, make this carrier have ability of promoting producing and bone of blood vessel to regenerate at the same time. Researchers isolate people's VEGF and BMP gene first, and then plant these genetic fragments into DNA which recombinate the relevant virus of gland, construct one pair of genes out and express and recombinate the relevant virus carriers of gland together. The result made in cytologic test verifies, VEGF and BMP albumens has biological activity, can stimulate the blood vessel to form and split up as bone effectively. Researchers further apply this carrier to animal's body. The result of animal's experiment shows, this carrier can produce the malposition to ossify in rabbit's lower extremities muscles. Researchers say, the implementation of this research has offered the experiment foundation for early gene therapy of osteonecrosis, can be used for trying to carry on the other diseases of the domain of dept. of orthopedics, the therapeutic research that for instance the bone does not connect with etc..


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